Pharmacology 2060A/B Study Guide - Midterm Guide: Median Lethal Dose, Therapeutic Index, Median Toxic Dose

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Andrea Di Sebastiano

Document Summary

Dose response curve and dose of drug on x axis, pain relief on y axis, you can see effective dose 50. Dose that is effective to produce 50% of the therapeutic response in 50% on the patients. Y axis shows the number of patient that respond, ed dose is the effectively responds to. 50% of the population, on an individual basis. Ed50 in module 9 refers to a population. Important to use animals to figure out ld50 and td. Effective dose 50 is significantly lower than toxic dose 50, lower than lethal dose 50. If the effective dose was 10 mg, and all patients respond and have n effective dose at 20, you would never need to administer a drug in the toxic range (30 mg) or in the lethal range. If our effective dose 50 is relatively low, and td or ld is a larger number, the therapeutic index will be higher, and thus will be safer drugs.