BIOL 4030 Study Guide - Midterm Guide: Tachyphylaxis, Myalgia, Antipruritic
26 Aug 2020
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Anti- inflammatory, inhibit epidermal proliferation and alter immune reactions. 1st choice for mild- moderate. 4 weeks (sustained results with continued application) Promote keratinocyte apoptosis, decrease cell respiration, inhibit inflammation. Most useful for thinning plaques. Ci: rosacea, acne vulgaris, perioral dermatitis, perian and genital pruritus (if pote topical steroid used) Burning/irritation at application site, pruritus, dryness, atrophy. Acne, contact dermatitis, photosensitivity, odour, sk and hair stain. Ci: diffuse, acutely inflam or open wounds. Burning, stinging, dryness staining of skin, clothes. Ci: flexures or on genitals inhibits epidermal proliferation; antiinflammatory. Biologically active metabolite of d3. Normalizes keratinization, suppresses hyper- keratinization, reduces inflammation. Effective in inflammatory conditions since they suppress pro- inflammatory cytokines. Risk of hypercalcemia if us extensively. Uv light to induce skin tumors. Irritating to mucous membranes and eyes. Skin burning, pruritus, skin erythema, fever, headach. Second line (moderate to severe): 1/3 patients. Phototherapy (alone or with topical/systemic)
