CHE 3332 Study Guide - Quiz Guide: Acyl Halide, Electrophile, Haloform Reaction
12 Feb 2018
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Acid halides: make it using an acid, 4 reactions using it to go down. 3 reducing it to an alcohol: 2 reactions - gilman v. grignard. *1 way: must know mechanism (fischer esterification: 5 overall reactions; reagents scattered amongst them. 3 ways: hydrolysis of amides -- acid vs. 2 ways: hydrolysis of nitriles -- acid vs. Basic ways: 2 reactions (grignards + reducing them to amine!) Either the o or c-end attacks the electrophile. More reactive than enols since they are charged. If alpha proton has a low pka : use weak base (etona) *will need to look through mechanism to see where it adds* Remove halogen; leave a double bond behind. Alpha bromination of carboxylic acids the hell-volhard-zelinsky reaction* Puts a halogen on the alpha position of a c. acid. Will need to be able to draw + label mechanism. It may be hard to stop over halogenation.
