BIOL 4330 Study Guide - Midterm Guide: Macrophage, Conformational Change, Horse Length
Document Summary
Hemoglobin critical protein involved in gas transport: all hemoglobin in body is going to be synthesized before leaves bone marrow, 10^6 per red blood cell, gene expression in rbc is tightly controlled. Iron dictates hemoglobin production: heterotetramer, each can bind 1 oxygen molecule, oxygen binding to hemoglobin is cooperative binding, enables it to deliver 1. 7x as much oxygen than if it were not cooperative. Inside a rbc it will be protected from break down. Study guide: hgb can combine with nitric oxide in the lungs; this helps relax arterioles ensuring that o2- rich blood circulates. Importance and involvement at the pulmonary and systemic capillaries: will ultimately be able to drive gas exchange. Fi(cid:272)k"s la(cid:449: oxygen and carbon dioxide, factors that influence simple diffusion, rate of diffusion is proportional to the surface area x the concentration gradient x membrane permeability / membrane thickness, permeability to the gas. Oxygen loading: air gets into alveoli before it gets transported into the blood.
