GEN-3000 Study Guide - Midterm Guide: Metaphase, Aneuploidy, Meiosis
Document Summary
Has to be a big enough piece to be considerable. If there is duplication, chromosomes will loop out when trying to line up. It curls away the duplicated information: types a. i. Tandem duplication right next to itself abc abbc a. ii. Displaced duplication on another spot on the chromosome. Unequal crossing over when the genes don"t line up correctly, causing duplication b. ii. Gene dosage a balance of gene products that you must have for certain phenotypes b. ii. 1. Duplication can mess up this balance and change phenotype: deletions taking away some of the chromosome. Balance - thrown off just like duplication b. ii. Pseudodominance if the wild type allele gets deleted, you many now see the bad recessive alleles/phenotypes. Recessive allele acts in a dominant but is not truly dominant b. iii. Haploinsufficiency you have 2 wild type alleles, if you lose one you still have another wild type allele but its not enough to show that phenotype.
