NSCI 4053 Study Guide - Midterm Guide: T Helper Cell, Protein Folding, Cytotoxic T Cell
19 Dec 2016
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Variability in aa composition allows ab to irreversibly bind to specific targets. Identify foreign molecules and targets them for destruction. Humoral immune response: b-lymphocytes secrete ab that bind to invading substances causing aggregation of the pathogen and flags it for destruction by macrophages. Antigen: the invading substance that elicits an immune response. Antibody: the specific immunoglobulin that binds to the antigen. Some substances attract multiple antibodies each binding to its own epitope. Epitope: regions on the surface of the invading substance and commonly composed of a group of surface sugars or aas that attract certain abthese regions are what the ab are made to target. Can produce diversity of ab with different aa. After the initial exposure, memory allows for more rapid response the second tim. During development, the lymphocytes are exposed to self-antigensthe antibodies that attack self are flagged and are not stimulated for replicationissues in this system lead to autoimmune disease.
