NURS 2060 Final: Final Exam Study Guide
Document Summary
(cid:315) ph (due to lactic acid accumulation) Intracellular na accumulation: disruption of ribosomal interactions w/ er. Cm damage is a central factor in the pathogenesis of irreversible cell injury: lysosomal membrane injury (leakage of enzymes into cytoplasm) Impairment of cell volume regulations: failure of na/k pump. Cell swelling (h2o follows na+, so na accumulation intracellularly will have accumulation of h2o also) Nonspecific/innate: inflammation, natural barriers (intact skin, epithelial membranes) Specific/acquired/adaptive: humoral immunity (b lymphocytes), cell-mediated immunity (t lymphocytes) 1st line: lysozyme in most secretions, mucus, sebaceous gland secretions, cilia lining trachea, skin, acid in stomach, commensal organisms in gut and vagina, spermine in sperm. 2nd line: inflammatory response (nonspecific response to tissue insult or invasion) 3rd line: goals of inflammation = mobilized large # of neutrophils, monocytes, and plasma proteins to area of injury. Describe the vascular response what it is and the results. Vasodilation (increases blood flow to specific area) Migration of wbcs to site of injury.
