BIOL 4087 Study Guide - Final Guide: G Protein–Coupled Receptor, Receptor Tyrosine Kinase, Adrenergic Receptor
Document Summary
General features of signal transduction: g protein coupled receptors: b adrenergic receptor. 12-1: 1) specificity- signal molecule binds to a receptor. Low kd: 2) amplification- enzyme cascades multiple turnovers nm signal effect. The activated receptor interacts w/ cellular machinery, producing a second signal or a change in the activity of a cellular protein: 3) modularity- interchangeable parts; regulated by phosphorylation. The metabolic activity of the target cell undergoes a change: 4) desensitization/ adaptation- continuous signal turn off receptor or remove from plasma membrane, 5) integration- multiple signals unified response, 6) the transduction event ends. G protein-coupled receptors (gpcr or 7tm or serpentine) with -adrenergic receptor as example (fig. 12-6), a kinase anchoring protein (akap: when camp is the low, two identical regulatory subunits (r; red) associate w/ the two identical catalytic subunits (c). R2 dimer, the site of binding to an. These proteins share a region of sequence similarity around the ser or thr residue that undergoes phosphorylation.
