GENE 540 Study Guide - Midterm Guide: Cancer, Tumor Suppressor Gene, E2F
Document Summary
When cell cycle is not regulated like it should be, bad things happen; such as retinoblastoma (tumor in the retina) this is a malignant neoplasm of retinal origin. In order to inactive prb, dna tumor viruses express proteins to hyper-phosphorylate prb, which causes it to be released from e2f (transcription factor) The 2 copies are segregated during the m-phase (this is a small fraction of the cell cycle - mitosis) 1/24 hours. For duplication (s phase) the allocated time is 7-8 hours. At the mitosis (prophase) the two sister chromatids are held together by a complex called cohesin (holds the 2 copies of the genome together) Cohesin holds 2 copies of the genome together as it leaves g2 and enters m- phase. During mitosis, the cohesion complexes are localized to the centromeric region. Mitosis is a phase of the cell cycle; it has sub-phases: prophase, prometaphase, metaphase,
