BIO 361 Study Guide - Midterm Guide: Crtc2, Cytokine, Cytostasis
9 Aug 2018
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Inhibits alpha-ketoglutarate oxygenases: extensive epigenetic modifications to dna in cancer. Increase histone methylation: soft agar growth and cytokine independence. Pep to become pyruvate: 2-pg produced heavily, the backwards step, fatty acid synthase (fasn) is overexpressed in a number of cancers. Inhibitors are antiproliferative towards tumor cell lines: orlistat inhibits both fasn and lipases, ampk regulates carbohydrate and lipid metabolism enzymes, sustained activation inhibits tumor growth, activates glycolysis by activating pfk-2, which makes f2,6bp that activates pfk-1. Inhibits acc to bring down malonyl-coa, which allows cpt1 activation to move fa into mitochondria for beta-oxidation. Increases recruitment of glut4 to plasma membrane to express gene expressing glut4 and facilitate insulin-independent uptake of glucose: liver gluconeogenesis, fatty acid biosynthesis and steroid synthesis are inhibited. Inhibits torc2 -> inhibits transcriptions of gene encoding. Pepck -> turn off gluconeogenesis to conserve atp. Inhibits acetyl-coa carboxyulase (acc1) to bring down fa synthesis.
