GENE 320 Study Guide - Midterm Guide: Tata Box, Rna Interference, Microrna
Document Summary
Xp caused by thymine dimers not being excised out of the dna. This is because there"s some problem with the ner pathway. Duplication can later become mutated and cause a new function for a gene. Cnvs and the different combinations of sequences can express different genes. Fragile x/fragile sites - sequences repeated over and over again -> makes regions of the chromosome very fragile and prone to breakage. Gc, ccaat, tata box mirna (rna interference) affect on mrna and the expression of certain genes hypermutations + recombinations = more variation within the genome that might help provide defenses for the body* Understand p53 and the way it works know examples of proto-oncogenes & tumor supressors. Cloning question about a plasmid - marker detection when sequence/dna of interest has been copied. White = cloned w/ dna that disrupts lacz gene. Blue = cloned but nothing disrupting lacz gene cdna made from rna template strand.
