BIOL 4376 Study Guide - Quiz Guide: Methotrexate, Ciprofloxacin, Gram-Positive Bacteria
1 Jul 2020
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Infectious disease quiz 2 material by mark chen. Most antibiotics were developed in the 1950s and not in the 2000s. We have not had any novel mechanisms of actions against gram negative rods since the late 60s. Cell wall synthesis: beta lactams, penicillins, cephalosporins, carbapenems (imipenem, monobactams (aztreonam, glycopeptides (vancomycin) Protein synthesis (ribosomes: aminoglycosides (gentamicin, macrolides (erythromycin, streptogramins (quinupristin/dalfopristin, lincosamides (clindamycin, tetracyclines (doxycycline, chloramphenicol, fusidic acid. Dna replication (dna gyrase: quinolones (nalidixic acid, ciprofloxacin) Folate metabolism: trimethoprim, sulphonamides, cell wall synthesis, cell membrane function, dna synthesis and function, protein synthesis. Bacteria have cell walls which we do not (no toxicity against humans) some target cell membrane (we share with bacteria, so the drugs are more selective). Protein synthesis: target transcription, or targets translation at the ribosomal level. Dna synthesis and function: block a precursor or purines and pyrimidines. Pharmacodynamics: drug patient (what the drug does the patient) Pharmacokinetics: patient drug (what the patient does to the drug)
