B STR 301 Study Guide - Midterm Guide: Genetic Disorder, Natural Killer Cell, Sinoatrial Node

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WEEK 6 OBJECTIVES
1. Describe the components of the circulatory system and its
general function.
- Consists of heart, blood vessels, and blood
- A pump with circuits to deliver oxygen, nutrients, and other products to tissues and
cells
- Removes wastes from tissues and cells
-Blood vessels:
oArteries: carry blood away from the heart
oVeins: carry blood towards the heart
oDeoxygenated blood: low amount of oxygen
oOxygenated blood: high amount of oxygen
-Pulmonary circuit:
oBlood flows from the RIGHT heart to the LUNGS and back to the heart
oGas exchange in the LUNGS
Blood becomes OXYGENATED (oxygen is added to the blood by the lungs)
-Systemic circuit:
oBlood flows from the LEFT heart to all BODY ORGANS and back to the heart
oGas exchange in ORGANS
Blood is DEOXYGENATED (oxygen is released to the organs)
2. Describe the basic components and properties of blood.
-Blood functions:
oTransport materials around the body
Nutrients
Glucose
Salts
Taking away waste products from the cells
oHomeostasis
pH
TB (basal body temperature)
Hydration of cells (blood is mostly water)
oProtection against fluid loss (clotting) and disease (white blood cells)
-Blood characteristics:
oType of fluid connective tissue
opH range= slightly basic (7.35-7.45)
ovolume: males tend to have a bit more blood
5-6L in males
4-5L in females
oPlasma (liquid portion) + formed elements (packed cell volume)
-Components and general properties of blood:
oPlasma:
Clear, extracellular fluid (matrix)
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WEEK 6 OBJECTIVES
55% of whole blood
Water (92%)
Suspended substances:
Plasma proteins
Ions
Nutrients, hormones, and waste products
Dissolves gases
oFormed elements:
Cells and cell fragments
Make up about 45% of whole blood
Erythrocytes (red blood cells)
Leukocytes (white blood cells)
Platelets (thrombocytes)
Myeloid Hemopoiesis: occurs in red bone marrow
Production of blood cells in bone marrow
All types of formed elements are produced in red bone marrow
3. Explain the basic functions of each of the blood proteins
-Types of plasma proteins:
oAlbumin (60%):
Colloidal osmotic pressure
Filtration/flow of water from capillaries  tissues
More albumins = greater pick up of fluids from tissues into
capillaries
Buffer
Transport (bilirubin)
Some things are not water soluble, so you need to attach protein
in order to have them move through the blood
oGlobulins (36%):
Immunoglobulins: antibodies for body defense against infection
Complement: chemicals for defense against infection
Transport:
Transferrin: iron
Lipoproteins (VLDL, LDL, IDL, HDL): cholesterol
oFibrinogen (4%):
Blood clotting protein
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WEEK 6 OBJECTIVES
4. Describe the structure and function of erythrocytes
- Function to TRANSPORT OXYGEN
- Secondarily to transport CO2
- About 5million/microliter of blood
-Erythropoiesis: production of red blood cells
oOccurs in the
red bone marrow of long bones, ribs, sternum after puberty;
spleen and liver of fetus
oHormones stimulate erythropoiesis:
erythropoietin: a peptide hormone from kidneys, released due to
hypoxia (low tissue oxygen levels)
testosterone
-Hematocrit: measures oxygen carrying capacity in blood
oamount of erythrocyte/RBC in blood
opacked cell volume
onormal values
males = 45%-52%
females = 37%-48%
5. Discuss the formation, life span, and death or erythrocytes
- No nucleus
- Size: slightly smaller than capillaries
- Biconcave disc
oMaximizes surface area to volume ratio
oDecrease diffusion distance
oAllow cell to flex when moving through small capillaries
-Erythrocyte life cycle:
oErythropoiesis: production of RBC
Originate from hemopoietic stem cells
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Document Summary

Week 6 objectives: describe the components of the circulatory system and its general function. A pump with circuits to deliver oxygen, nutrients, and other products to tissues and cells. Blood vessels: arteries: carry blood away from the heart, veins: carry blood towards the heart, deoxygenated blood: low amount of oxygen, oxygenated blood: high amount of oxygen. Pulmonary circuit: blood flows from the right heart to the lungs and back to the heart, gas exchange in the lungs. Blood becomes oxygenated (oxygen is added to the blood by the lungs) Systemic circuit: blood flows from the left heart to all body organs and back to the heart, gas exchange in organs. Blood is deoxygenated (oxygen is released to the organs: describe the basic components and properties of blood. Blood functions: transport materials around the body. Taking away waste products from the cells: homeostasis. Hydration of cells (blood is mostly water: protection against fluid loss (clotting) and disease (white blood cells)

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