BIO SCI 97 Study Guide - Final Guide: Spermatogonium, Ndc80, Transgene
19 Apr 2016
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Immature undifferentiated cells non-specific cells: stem and progenitor cells, mature differentiated cells specific cells, all different cell types ex. Notch-delta signaling development to specify the identity of a cell from a uniform population of cells. Lecture 15: core components of a simple signaling pathway. Signal reception, signal amplification, and signal execution i: receive information iii. relay information from the membrane to the transduction/amplification machinery, amplify the signal. Integrate the signal with other signaling pathways v. vi. modulate the signaling pathways vii. produce a long-term physiological change: cell signaling involves intracellular amplification of extracellular signals, thee ore steps in signaling cascade, the greater the signal amplification, ex. Pka or pkc are not second messenger: used to refer to small molecules that can diffuse rapidly and whose concentration changes rapidly following receipt of signal, second messengers are chemically diverse small molecules that carry signals inside cell. Inorganic ion ca2+; organic compounds ip3; cyclic nucleotides .
