BIO SCI E124 Study Guide - Midterm Guide: Fragment Crystallizable Region, Immunoglobulin Light Chain, Phagocytosis
Document Summary
Enter light zone --> become centrocytes after division stops--> increase expression of surface ig (immunoglobin). In light zone, centrocytes interact with follicular dendritic cells and t helper cells. Follicular dendritic cells bind to antigen-antibody complexes while centrocytes compete to bind to antigen. High affinity b cells for membrane hemoglobin succeed . B cells that survive antigen selection receive survival signal from th cells. -> differeintie into memory b cells or antibody secreting plasma cells. Progenitor (pro b cell) - expresses cd45r (tyrosine phosphatase) Pro b cells --> precursory (pre-b cells) by proliferation and differintiation. Stromal cells provide microenivromment that directly interacts with pro_b and pre b cells by secreting various cytokines. Antigen-antibody complex encapsulated by receptor-mediated endocytosis--> degraded to peptides. Th cell recognizes antigen-class ii mhc on b-cell membrane + co-stimulatory signal => activates th cell. Class i and class ii mhc molecules are membrane-bound glycoproteins. They reduce the replication rate of the virus.
