MCB 2000- Final Exam Guide - Comprehensive Notes for the exam ( 43 pages long!)

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What determines polarity: arrangement of electrons in a covalent bond, equal sharing, uniform charge distribution: molecule is nonpolar (no dipole or electronegative atoms, unequal sharing, asymmetrical distribution: molecule is polar because the bond involves an electronegative atom: o. Common electronegative atoms in biological systems: oxygen > nitrogen> Sulfur: polar covalent bonds, electrons not equally shared btwn atoms, relatively reactive. Why is polarity important: partial charges explains how reactive a molecule is, explains why molecules are hydrophilic (water loving) or hydrophobic (water fearing, importance of water as an organizing principle in biology, leads to noncovalent interactions. Noncovalent interactions: van der waals forces, h-bonds, electrostatic, ionic interactions, hydrophobic interactions. H-bonds: not covalent (repped by a dotted line, break and form spontaneously/ short lived, occurs btwn electronegative atom (acceptor) and an h atom that is covalently bonded to another atom (donor) Why are many salts soluble in water: because sodium chloride in water would ionize (separate)because water has partial charges.

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