BICD 100 Study Guide - Midterm Guide: Hh Blood Group, Dihybrid Cross, Abo Blood Group System

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Novel phenotypic ratios: ex: alterations of mendelian 3:1 ratio in agouti mice (agouti is black/yellow mix) Crossing 2 agouti mice will produce all agouti mice. Can also have yellow coat color; yellow dominant to agouti for color, but recessive for lethality. Crossing 2 yellow mice will produce 2/3 yellow and 1/3 agouti. In recessive allele, there is a raly gene present that is required for mouse embryonic development and an agouti gene for moderate yellow pigment. In dominant allele, the raly gene and agouti promoter are deleted, so the raly promoter expresses the agouti gene, changing the amount of pigment in the mice. Only one raly gene is required for development, but since homozygous dominant mice have no raly gene, they fail to develop and are lethal. Separate gene b, determines whether mice are albino. bb mice are albino, regardless of other genes. Parent generation: agouti x albino; aabb x aabb. F2: final phenotypic ratio is 9:4:3, agouti: albino: black.

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