BISC401 Study Guide - Midterm Guide: Copii, Intron, Pabpn1
22 Dec 2016
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Document Summary
Variable region, dna-binding domain, and ligand-binding domain = nuclear receptors for activation of transcription. When you put a hormone into the mix, it starts locating there. Processing of pre-mrna: alternative cleavage, mrna made dependent on which poly(a) site selected during processing. Dna from adenovirus: need to loop out other regions for dna-rna hybrid to form. Alternative splicing permits different proteins to be made in different tissues: for example, fibronectin. Self-splicing introns: group iii: spliceosome-catalyzed splicing of pre-mrna, group i and group ii, chemistry the same between ii and iii, ***chemistry of splicing reaction. Spliceosome-catalyzed splicing: how spliceosome is assembled, u2a(ssociated)f(actors) Snrnas in snrnps base pair with pre-mrna during splicing: snrnps are snrnas associated with proteins. Splicing critical for sex determination in drosophila: can stop splicing reaction by masking the sites that recruit splicing factors; in- frame stop codon on exon 3; sxl protein splices out exon 3; this makes more of the.
