NURS222 Study Guide - Midterm Guide: Polystyrene, Prilocaine, Palpitations
5 Apr 2016
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Only oral meds go through this stage (iv, im, sq skip this) Needs to disintegrate and dissolve (slowest process) to cross membrane (liquid is already ready to cross) Limiting acting rate: slow down medications working too fast: state, acidity, excipients or filler, pharmacokinetic: Absorption, distribution, metabolism, excretion: absorption: iv- im- sq-po (fast to slow) Blood flow, pain, stress, hunger, ph all affect this. First pass effect: goes to liver first (looses some bioavailability: distribution. Blood links to proteins and carries drug threw body. Active drug: not attached to protein (hopped off) Effect varies on persons size (concentration: metabolism. Time half of drug is metabolized and eliminated. Long= around for awhile; short= small time: excretion. Kidneys most common (urine); or other (exhale, skin, etc) If not well, wont excrete meds and build could be toxic. Assessment: glomerular filtration rate: creatinine clearance: normal= 85-136 ml/min, bun: urea, pharmacodynamics.
