MICROBIO 310 Study Guide - Quiz Guide: International Standard Serial Number, Cell Press, Gut Flora
30 Jun 2016
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25 february 2016, pages 859-871, issn 0092-8674, http://dx. doi. org/10. 1016/j. cell. 2016. 01. 024. It turns out that milk is necessary but not sufficient for infant growth. Recently, a study has found out that decreased human milk oligosaccharides (hmos) are associated with mothers with stunted children. Stunting is currently the most common type of undernutrition, leading to neurodevelopmental impairment. However, even though previous studies have suggested that disrupted assembly of gut microbiota prevents postnatal growth, there is still a lack of documenting the relationship between human milk and growth of infants, with regard to undernutrition. First, hmos were identified from two groups of malawian mothers with either healthy or severely stunted 6-month-old children. Isolated bacterial strains from fecal microbiota of stunted infant were colonized into mouse models. Then these mice were fed with two diets: either with or without added sialylated bovine milk oligosaccharides (s-bmos), structurally similar to hmos.
