CHEN 3701 Study Guide - Final Guide: Fructokinase, Hexokinase, Glyceraldehyde 3-Phosphate
7 Jun 2019
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A cell intakes 10 pmol/day of fructose (f). The hexokinase enzyme catalyzes phosphorylation to fructose-6- phosphate (f6p) whereas fructokinase catalyzes phosphorylation of fructose to fructose-1-phosphate (f1p). F6p can be further metabolized via glycolysis; also, 3 pmol/day of f6p are. While dhap is a glycolysis intermediate, ga needs to be phosphorylated. Which consumes an atp to glyceraldehyde-3-phosphate (g3p). Exported" to other processes via f6p, ga, or pyruvate (p, produced via glycolysis). It should be noted that hexokinase is present at a 2-fold higher concentration than fructokinase. The rate constants of these enzymes are also known: (pentose phosphate pathway). F1p to glyceraldehyde is converted kcat,hexokinase = 300 s-1 kcat,fructokinase = 200 s-1: sketch a simplified view of the metabolism that is a basis for your analysis. Metabolites not indicated above can be ignored entirely in the analysis. Label all reaction rates (ri) and transport fluxes (qi).
