NURS 165 Study Guide - Final Guide: Etanercept, Hydroxychloroquine, Leflunomide

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31 May 2018

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• NSAIDs (Nonsteroidal Anti-inflammatory Drugs)- rapid relief, do not prevent

joint damage or slow disease

• Nonselective- inhibit both COX1 and 2

• Ibuprofen

• Selective- inhibit only COX2

• Celecoxib

• Glucocorticoids- rapid relief, slow disease progression, toxicity with long-term

use

• Decrease mediator synthesis and lymphocyte proliferation

• Prednisone

• DMARDs (Disease-modifying Antirheumatic Drugs)- reduce joint destruction,

slow disease, slow onset of effects

• Nonbiologic/Classic- synthetic

• Methotrexate

• Leflunomide

• Hydroxychloroquine

• Biologic- large molecules produced through recombinant DNA

technology

• TNF-antagonist

• Etanercept

• Inliximab

• IL-6 antagonist

• IL-1 antagonist

• B-cell-depleting agent (anti-CD20)

• T-cell activation inhibitor

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