PSY 3625 Study Guide - Midterm Guide: Psychomotor Agitation, Cognitive Style, Interpersonal Psychotherapy

• School: Vanderbilt University
• Department: Psychology (A&S)
• Course: PSY 3625
• Professor: Hollon Steven

Document Summary

Neurobiological aspects of depression: monoamine systems norepinephrine serotonin dopamine, norepinephrine: initiates maintains arousal in brainstem limbic system cerebral cortex (stress) Serotonin: modulates ne da and major role in energy regulation: dopamine: want it more than like it but involved in appetitive motivations (positive) Stress monoamines and the hpa axis: antidepressants monoamine receptors and intracellular mechanisms, glutamate nmda receptors and ketamine (next wonder drug?) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders: glucocorticoids mobilize to deal with stress, adaptive in short term (ready body for fight/flight) Excessive cortisol burns out cells in hippocampus: rich in receptors to provide inhibitory control on hpa, reduced hippocampal volume in depression, neurotoxic effects could be, reduces dendritic branching. Inhibits genesis of new neurons: kills existing neurons. Is influenced by: brain-derived neurotrophic factor (bdnf, cortisol/stress systems. Provides regulation of: cortisol/stress systems, dopamine/basal ganglia systems. Cortisol kills neurons in the hippocampus: hippocampus acts as brake on hpa and amygdala.