BIOL 261 Chapter Notes - Chapter 18: Genotype Frequency, Gene Pool, Panmixia

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tanfly906

30 Nov 2016

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Gene pool = the sum total of all alleles in the breeding members of a population at a given time. The frequency of an allele in the gene pool is equal to the probability that the allele will be chosen when randomly picking an allele from the gene pool to form. In africa, albinism is present at frequencies as high as 1 in 1100 among some ethnic groups in an egg or a sperm =(cid:1868)2. Random mating: for example, a tendency for individuals who are phenotypically similar to mate with each other violates the hardy-weinberg law. If one of the genotypes has reduced viability such that some individuals with that genotype die before the genotype frequencies are counted, then the estimate of the gene frequencies will be inaccurate. The population must not be divided into subpopulations that are partially or fully genetically isolated.

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Q1. What are alleles?Different forms of the same gene.Different genes.The different characteristics of an organism.Genes found only in humans.Q2. If you add up the frequency of homozygotes + the frequency of heterozygotes for one gene (i.e. at one locus) in a population, what number do you get?Q3. People who are heterozygous for the sickle-cell allele:Are susceptible to malaria but not sickle-cell anemia.Are susceptible to sickle-cell anemia but not malaria.Are not susceptible to either sickle-cell anemia or malaria.Are susceptible to both sickle-cecell anemia and malaria.Q4. In the case study in this lab, which genotype is represented by "2pq" in the Hardy-Weinberg equation?Homozygous HbAHomozygous HbSHeterozygous HbA/HbSNo specific genotypeQ5. Suppose that, in an isolated village, the proportion of individuals that have sickle-cell anemia is 0.1 (or 1 of every 10 people). What proportion of the population should be sickle-cell carriers, according to Hardy-Weinberg expectations?Q6. When you simulated the elimination of malaria at the beginning of the lab, once the allele frequencies stabilized, what was the frequency of the HbA allele?Q7. When you investigated regional differences, what was the frequency (over many generations) of the HbS allele in the village in the "slightly wet" part of Africa?Q8. What is the number of deaths due to sickle-cell anemia in a region without mosquitoes expected to be?Very lowVery highModerateRelated to the frequency of malaria allelesQ9. As long as there are multiple alleles of a gene in a population, why will the frequencies of the alleles always change over time?Because natural selection changes all allele frequencies in populations over time.Because genetic drift causes random fluctuations of allele frequencies in populations.Because diseases will eliminate some of the alleles, generating fluctuations in their frequencies.Because allele frequencies fluctuate before the alleles eventually become fixed.Q10. Imagine a huge population with a gene that has ten functionally equivalent, neutral alleles. A small but genetically representative group of individuals from the big population is transported to an island, forming a small population. Which of the statements below best describes what will likely happen over time, and why?Because natural selection doesn't act on neutral alleles, the frequencies in the two populations should remain the same over time.Genetic drift will cause one allele to first become fixed in the island population, and later to become fixed in the original, large population.Genetic drift will result in the allele frequencies of the two populations diverging over time, with alleles being lost sooner in the island population.The allele frequencies of the two populations will change similarly due to a combination of genetic drift natural selection.

indigosnake469

1. A) Explain how changes in the environment drive evolutionary change. B) Provide and explain an example

2. A) Explain how the Hardy-Weinberg equation allows us to find evidence of evolution. B) Could processes other than Natural Selection result in deviation from the Hardy-Weinberg equilibrium? List and explain each one: C) define what the process is and D) the effect it has on the allele frequency.

3. A gene that is responsible for multiple traits (pleiotropy), for example the same allele causes sickle-cell anemia and provides resistance to malaria. Would a gene that controls these two traits respond equally to natural selection favoring malaria resistance as a non-pleitropic gene that only controls malaria resistance? Explain your answer.

4. A) Explain how lack of genetic variation limits evolution and provide an example. B) Explain how epistasis limits evolution and provide an example

Questions 5-6 are based on the following:

Letâs say you are studying a population of Japanese four oâclock plants. In these plants, the allele for red color flower shows incomplete dominance over the allele for white flowers. This is very convenient for this experiment because you can distinguish the heterozygous (pink flowers) from the homozygous dominant (red flowers). For your experiment, you produced a large number of plants, 25% had red flowers, 25% had white flowers and 50% had pink flowers. You transplanted them into different habitats and left some in the lab (using the same proportions in all the habitats). You waited a few years, while plants reproduce for a few generations and then you go back and resample the populations youâve transplanted.

5. In the lab you ensured that all individuals receive all requirements to grow and reproduce and mate randomly. A) What do you expect the distribution of the phenotypes after a few generations breeding in the lab? B) Is the lab population in Hardy-Weinberg equilibrium? Yes/No, explain

6. In habitat A, you find that you only have red flowering plants and white flowering plants but there are no pink flowering plants. A) Is the population in habitat A in Hardy-Weinberg equilibrium? Yes/No, explain. B) Which one(s) of the five agents of evolutionary change could be responsible for these results? Explain. C) What type(s) of selection (stabilizing, disruptive, directional, oscillating, etc...) could be responsible for the results in habitat A? Explain

plumdonkey701

Q1. Which of the following statements is true about the disease Kuru?
Kuru is caused by a virus, which is contracted by eating human brain material.
Kuru is caused by a prion (PrP), which is contracted by eating human brain material.
Kuru is caused by a recessive allele for PrP; if a person has two copies, he or she will develop Kuru.
Kuru is caused by a dominant allele for PrP; if a person has two copies, he or she will develop Kuru.
Kuru is caused by having one copy of the dominant allele and one copy of the recessive allele for PrP.

Q2. True or false: One can calculate the frequency of alleles in a population if the genotypes of the members of the population are known.

True False

Q3. The Hardy-Weinberg equation is p2 + 2pq + q2. In this equation, q2 stands for the frequency of ____________ in a population.

The recessive allele O

ne of the homozygous genotypes

The dominant allele

Heterozygous genotype

Q4. Which of the following descriptions best fits the relationship between the terms gene, allele, locus, and chromosome?

Alleles are different forms of a gene, which can be found at a locus on a chromosome.

Genes are made up of chromosomes, which can be found at a locus on an allele.

Chromosomes are different forms of a gene, which can be found at an allele on a locus.

A locus is made up of alleles, which can be found at a gene on a chromosome.

Q5. Mead and his colleagues proposed a hypothesis for the apparent heterozygote advantage for the PrP locus. What did they suggest as the basis for the high presence of both alleles?
History of cannibalism.
Protection from malaria.
Protection against plague.
They did not propose a heterozygotic advantage for the PrP locus.

Q7. A frog population has two alleles for skin color at the following relative frequencies: Allele SC1= 0.8, Allele SC2 = 0.2. Allele SC2 is:
Dominant
Recessive
Co-dominant
Impossible to determine dominance from the information given.

Q8. A bird population has two alleles for feather color at the following relative frequencies: Allele FC1 = 0.5, Allele FC2 = 0.5. Allele FC1 is:
Dominant
Recessive
Co-dominant
Impossible to determine dominance from the information given.

Q9. Use the following information for both questions 9 and 10: You encounter a few populations of millipedes with variation in skin color. Genotype can be inferred from coloration: CC millipedes are black, Cc millipedes are brown, and cc millipedes are yellow. [You can launch a calculator byclicking here.]

If one millipede population has 60 black individuals, 20 brown individuals, and 20 yellow individuals, what is the relative frequency of allele C in that population?

0.5
0.6
0.7
0.8
Impossible to calculate from the information given.

Q10. If another millipede population's allele frequencies are 0.5 for C and 0.5 for c, what is the expected frequency of the cc genotype in the population, if the population is in Hardy-Weinberg equilibrium?
0.125
0.25
0.5
1.0
Impossible to calculate from the information given.

greenskunk262

BIOL 261 Chapter Notes - Chapter 18: Genotype Frequency, Gene Pool, Panmixia

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