PHGY 311 Chapter Notes - Chapter 6: Resting Potential, Lipid Bilayer, Nernst Equation
23 Sep 2017
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Recording membrane potential: place glass micropipettes filled with concentrated salt solution (electrodes) on either side of the membrane, wire passing through record amplitude of membrane potential (v, differential recording. Ion flux = (electrical + chemical driving force) x (membrane conductance) In most mature neurons, cl- movement makes er more -, but in some (usually immature) can make it more + Action potential: opening of voltage-gated na+ channels, does not reach equilibrium potential of sodium since still have k+ efflux & cl- influx, then repolarization due to inactivation of sodium channels and opening of voltage-gated potassium channels. Goldman equation: permeability determines relative ion contribution. Functional properties of neuron: equivalent circuit: model to represent important electrical properties of neurons, lipid bilayer provides membrane with capacitance. Ionic current depends on how many channels opened (conductance) and difference between electrical (vm) and chemical (ek) driving forces.
