BIOLOGY 3UU3 Chapter Notes - Chapter 20: Sirolimus, Peroxidase, Homeostasis
13 Apr 2017
School
Department
Course
Professor
Document Summary
Oxidative stress and aberrant signaling in aging and cognitive decline. Age-related derangement of redox-regulated signals (cid:120) ros production by various tightly regulated nad(p)h oxidase, isoenzymes is known to play a role in many redox-sensitive signaling pathways. It can also regulate cell survival by deactivating the tumor suppressor, p53: the exact role of sirtuin in the aging process remains unclear. Its reduced form recycles several antioxidants such as gsh, and vitamins c and e. Feeding la to mice was shown to have a positive effect on brain mitochondrial functions and was shown improve spatial learning and memory. In independent studies on mice, rats and fruit flies, the increased survival of calorically restricted animals was associated with a decrease in tissue oxidative damage. Increased life span was correlated with increased oxidative stress resistance in worms, flies, and mice. Putative mechanisms accounting for the age-related increase in oxidative damage: changes in antioxidant enzymes (cid:120)
