BIOL 200 Chapter Notes - Chapter 7: Spindle Apparatus, Histone H1, Sister Chromatids
Document Summary
Prior to the onset of m-phase, the cell has gone through several events to prepare itself. One of the most important, from a survival perspective, is the duplication of its dna. Cells that are too small may successfully divide (and survive), but cells without a fully duplicated set of dna will not. We begin this topic with a discussion of the mitotic chromosome, followed by an examination of the events of mitosis, and how the cytoskeleton plays an important role in this. As a reminder, a chromosome is a linear dna molecule with three specialized dna sequence regions: telomeres at each end, to protect the ends of the chromosome, centromere. The centromere is a special dna sequence that is the site at which the spindle microtubules attach at mitosis: at least one origin of replication, where the dna synthesis machinery binds to duplicate the chromosome.
