MICB 202 Chapter Notes - Chapter 4: Viral Envelope, Gp41, Envelope Glycoprotein Gp120
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Aids (acquired immunodeficiency syndrome) characterized by the susceptibility to opportu(cid:374)isti(cid:272) pathoge(cid:374)s a(cid:374)d the o(cid:272)(cid:272)urre(cid:374)(cid:272)e of kaposi"s sar(cid:272)o(cid:373)a or b (cid:272)ell l(cid:455)(cid:373)pho(cid:373)a (cid:894)results in profound loss of cd4-positive t cells) Average time from initial infection to disease progression is longer for hiv-2 than hiv-1. Diploid genome consists of two identical ssrna. S(cid:455)(cid:374)thesized a(cid:374)d pro(cid:272)essed (cid:271)(cid:455) host (cid:272)ell (cid:373)rna (cid:862)ha(cid:374)dli(cid:374)g (cid:373)a(cid:272)hi(cid:374)er(cid:455)(cid:863) after i(cid:374)tegratio(cid:374) of (cid:448)iral. Dna into chromosome (+) rna but does not serve as mrna immediately after infection. Associated with specific trna (derived from host) used as prime replication. Rna (cid:272)o(cid:374)tai(cid:374)s (cid:1009)" (cid:272)ap a(cid:374)d (cid:1007)" pol(cid:455)a tail. Sa(cid:373)e ge(cid:374)e order i(cid:374) all retro(cid:448)iruses: (cid:1009)" gag pol env (cid:1007)". (cid:862)co(cid:373)ple(cid:454)(cid:863) retro(cid:448)iruses (cid:894)hiv-1) contain additional genes that are involved in regulation of gene expression. Viral encoded glycoprotein (two protein subunits held by disulphide bond) on surface of envelope. Subunits are derived from product of env gene (gp160) enzymatically cleaved by cellular protease: Gp120 anchored to viral envelope via gp41.
