PSYC 462 Chapter Notes - Chapter 1: Portal Vein, Biotransformation, Abdominal Wall
Document Summary
Book title: psychopharmacology: drugs, the brain, and behavior 2nd edition. Pharmacokinetics: pharmacokinetic components of drug action determine the variable bioavailability of drugs and how such factors interact in a dynamic fashion that influence the effect they have on the person. Routes of administration different routes determine the amount of time the drug takes to be absorbed into the blood and reach receptor sites of action. Absorption and distribution passing through phosphoplipid cell membranes and travelling along in the blood circulation to reach target drug receptors. Binding drug molecules may bind to different components such as desirable receptor sites or inactive storage depots such as plasma proteins, bone and fat. Inactivation biotransformation is when liver enzymes change drug into inactive form for excretion. The more the drug is inactivated or metabolised, the lesser the bioavailability. Excretion after biotransformation into inactive liver metabolites, the drug is removed from the body with urine or faeces: methods of drug administration:
