HSS 2305 Chapter Notes - Chapter 14: Chronic Myelogenous Leukemia, Cri Du Chat, Patau Syndrome
21 Nov 2018
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Small scale modification: deletion of nucleotide pair, substitution, of nucleotide pair, insertion of nucleotide pair, single gene mutations autosomal dominant (i. e huntington"s disease, dwarfism, extra fingers/toes), autosomal recessive (cystic fibrosis, albinism, sickle-cell anemia), sex-linked (colour blindness, hemophilia) Trisomy 13 (patau syndrome: aneuploidy of sex chromosomes from nondisjunction of x or y chromosome, klinefelter syndrome (xxy), turner"s syndrome (single x chromosome, female looking, infertile), super female (xxx), super male (xyy) Familial inheritance run in families but means of inheritance are not completely understood: effects of several genes working together and addition or lack of environ influences i. e diabetes, allergies. Disease from major types of chromosomal abnormalities: an organism may be affected by small-scale changes involving individual genes, random mutations make new alleles, which can leave to new phenotypic traits. Mitosis cell division of almost all eukaryotic cells. 3: division of mother cell into 2 genetically identical daughter cells; diploid > n=46 (23 pairs)
