PHA 3112 Chapter 40: Methadone Substitution summary exam notes

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Pierre Fortier

Document Summary

Chapter 40: drug abuse iv: other major drugs of abuse. Initial exposure is either socially or context of pain management in medical setting. After iv heroin injection sensation in lower abdomen similar to sexual orgasm, k(cid:374)ow(cid:374) as (cid:862)rush(cid:863) or (cid:862)ki(cid:272)k,(cid:863) for 45 seconds after, e(cid:454)perie(cid:374)(cid:272)es prolo(cid:374)ged euphoria (cid:862)feeli(cid:374)g that all is well i(cid:374) the world(cid:863) First use: nausea & vomiting & overall sense of dysphoria. Prescription opioid analgesics are abused more commonly than heroin. Heroi(cid:374)"s high lipid solu(cid:271)ilit(cid:455) (cid:373)akes it eas(cid:455) to (cid:272)ross the bbb (cid:272)ausi(cid:374)g i(cid:373)(cid:373)ediate & i(cid:374)te(cid:374)se effe(cid:272)ts. Combo of speed & intensity of heroin differs from other opioids. Heroin can be administered by iv injection (greatest intensity, fast onset), smoking, or nasal inhalation (peak at 10-15 min) Orall(cid:455) or su(cid:271)(cid:272)uta(cid:374)eousl(cid:455) ad(cid:373)i(cid:374)istered heroi(cid:374) (cid:272)a(cid:374)"t (cid:271)e disti(cid:374)guished fro(cid:373) (cid:373)orphi(cid:374)e or other opioids cuz it rapidly converted to morphine (active form) in the brain. Oxycontin, controlled-released form of oxycodone to provide steady levels over extended time is abused.