PHA 3112 Chapter Notes - Chapter 56: Epoetin Alfa, Darbepoetin Alfa, Chronic Kidney Disease
10 Dec 2016
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Document Summary
Hematopoiesis: process where body makes rbc, wbc, & platelets regulated by hematopoietic growth factors. Hematopoietic growth factors: naturally occurring hormones that stimulate proliferation & differentiation of hematopoietic stem cells & enhance function in mature cell forms of those cells. Some forms also known as colony-stimulating factors. Therapeutic applications of hematopoietic growth factors: neutrophil & platelet repopulation acceleration after cancer chemotherapy, bone marrow recovery acceleration after autologous bone marrow transplantation (bmt), erythrocyte production stimulation in patients with chronic renal failure (crf). Interleukin-11: erythropoietic growth factors or erythropoiesis stimulating agents (esas): Erythropoietic growth factors (esas): stimulate production of erythrocytes (rbcs); use dropped cuz of; Adverse effects: increase stroke risk, increase heart failure risk, increase blood clots risks, increase mi risks, , increase deep vein thrombosis risk used prior elective surgery. In cancer patients, esa shorten time to tumour progression & reduce overall survival.
