PHA 3112 Chapter 12-13: Clinical Pharmacology Chapter 12 13; Basic Principles of Neuropharmacology & Physiology of the Peripheral System final exam summary notes

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Neuropharmacology: study of drugs that alter processes controlled by the nervous system. This initiates change in postsynaptic cell which depends on neurotransmitter type & cell type involved. If another neuron, may increase/decrease firing rate; if muscle cell, may contract/relax, if cell is glandular, may increase/decrease secretion. Figure 12-1 how neurons regulate other cells (t = neurotransmitter) Neurons alter receptor activity by releasing transmitter molecules diffuse across synaptic gap reversibly bind to receptors on postsynaptic cell. Drugs altering synaptic transmission can produce highly selective effects. Synapses at diff sites employ diff transmitters & body employs 1+ receptor for most transmitter. By using a drug that selectively influences specific type of neurotransmitter/receptor, we can alter 1 neuronally regulated process while leaving others unchanged = many uses. Impact of a drug on a neuronally regulated process is dependent on ability of that drug to directly or indirectly influence receptor activity on target cells.

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