CHM247H1 Chapter Notes - Chapter 20: Ketone, Nucleophilic Addition, Adsorption
Document Summary
Chapter 20: chemistry of carboxylic acids and nitriles. Aromatase is the enzyme responsible for estrogen synthesis. So these are anti-tumor drugs for estrogen stimulated tumors. Replace e in parent alkane name with oic acid . Eg/ (s)-3-ethyl-3-(p-methylphenyoxy) hexanoic acid: note: carbon count in hexanoic includes the cooh carbon. Eg/ 1-cyclopentene carboxylic acid: note: cyclopentene does not include the cooh. Complex nitriles are named as derivatives of carboxylic acids. Replace ic acid or oic acid or oxylic acid ending with onitrile. Carbonyl carbon is sp2 hybridized carboxylic acid group is planar with c-c=o and o=c-o bond angles ~120 . Strongly associated because of h-bonding: most carboxylic acids exist as cyclic dimers held together by two h-bonds, high boiling point (higher than corresponding alcohol) Acidic react with bases to give metal carboxylate salts, rco2. Carboxylic acids with more than 6 carbons are only slightly soluble in water but the alkali metal salts are.
