Biochemistry 2280A Chapter Notes - Chapter 4: Space-Filling Model, Alpha Helix, Coiled Coil
18 Jul 2016
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Document Summary
Biochemistry 2280 topic 3 protein structure. General protein functions: enzymes, structural proteins. Provide mechanical support to cells and tissue. Iron stored in liver by binding to ferritin protein: signal proteins. Nerve growth factor, epidermal growth factor: receptor proteins. Detect signal and transmit them to cell"s response machinery. Rhodopsin in retina detects light: gene regulatory proteins. Bind to dna to switch genes on or off. Lactose repressor in bacteria silences genes for lactase production: special purpose proteins. Antifreeze proteins of arctic and antarctic fish protect blood from freezing. Free energy (g) is minimized: folding process release heat (- h), increases disorder (+ s) Protein can be denatured by treated with solvents that disrupt noncovalent interactions holding folded chain together. After solvent removed, renaturation into same stable conformation occurs in correct conditions (best with small proteins) Misfolded proteins contribute to neurodegenerative disorders, i. e. alzheimer"s disease and huntington"s disease.
