Physiology 2130 Chapter Notes - Chapter 5: Troponin T, Acetylcholinesterase, Choline

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Describe the structural components of skeletal muscle, including muscle fibers, myofibrils, myofilaments, sarcomere, and the arrangement of the thin and thick myofilaments. Muscle fibers (cells): one of the few cells that have multiple nuclei. Myofibrils: within the muscle cell, long cylindrical structures that contain myofilaments of the muscle. Myofilaments: 2 types, thick and thin, that contain the contractile proteins of the muscle cell. Thin myofilament: made of actin, having an active site that allows binding of myosin. Thick myofilament: made of myosin, binds to actin active site when it is free site when it is free. Sarcomere: basic functional unit of the muscle, section of the myofibril. Z disks: where thin actin myofilaments extend outward in opposite directions. Groups of thin and thick myofilaments arranged in repeating pattern. Along length of myofibril from end to end of the muscle. Each myofilament is parallel to length of the myofibril and muscle cell. Z disk: where the thin myofilaments are anchored.

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