BIOL 2021 Chapter Notes - Chapter 17.5: Spindle Apparatus, Cdc25, Wee1
11 Feb 2018
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Q: how did wee1 get its name? (what would be the phenotype of a mutant yeast that lost wee1 activity) A: mutant cells enter mitosis too soon are small because mutant wee1 doesn"t inhibit m-cdk. M-cdk phosphorylates proteins and controls the assembly of mitotic spindles: breakdown of nuclear envelope by phosphorylating lamins: intermediate filaments underneath the nuclear envelope (give structure to the nuclear envelope) Re-arrangement of actin in the cytoskeleton and golgi. Chromosome condensation: 2 chromosomes, centromere, condensin: 5-protein complex that condenses chromosomes by forming a ring structure that encircles loops of dna within each sister chromatid. At the poles are centrosomes (minus ends of microtubules) The plus ends of microtubules radiate outward. There are 3 kinds of microtubules: interpolar: seem to go from pole to pole (antiparallel in the middle, kinetochore: attached to sister chromatids at the kinetochores, astral: radiate out from centrosomes to cell cortex.
