BIOL 2021 Chapter Notes - Chapter 2.2: Oncogene, Personalized Medicine, Blastula
2 Apr 2018
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An overactive oncogene can find an inhibitor. Gleevec/imatinib for treating leukemia: this cancer has a hyperactive tyrosine kinase, which causes proliferation and survival (cancer, occurs in cancer cells: cancer cells get further mutations in the cell that make them addicted to oncogenes. Genetic instability in cancer cells leads to a mutation in resistance: administer several drugs at once to the patient. One cell (fertilized egg) turns into many different cell types. Different cells make different proteins: structural-ion channels, signal proteins, and enzymes, egg reprogrammed the skin nucleus to act like an embryonic nucleus into an embryo. A fertilized cell becomes a blastula: hollow ball of cells. Then becomes a gastrula: cells are now different. Blastomere cells are totipotent: can make all cell types in a final adult through the process of differentiation/cell specialization. Terminal cell differentiation: final specialization in a cell: usually permanently stop dividing and are in the g0 stage of the cell cycle (exit the cell cycle)
