CRIM 2653 Chapter Notes - Chapter 10.8: Halothane, Immunoglobulin G, Autoantibody
23 May 2020
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Toxic hepatitis (halothane induced, metabolic idiosyncrasy: ast 740 (<35, alt 600 (<35, bu 150 (<20, bc 100 (<5, alp upper nr, viral serology neg, autoantibodies neg. Igg nr: liver insufficiency, pt, ammonia, bu compared to bc, low nr alb. In patient case, mediated by unusual metabolism of a drug called halothane. Bloodwork showed marked elevation of ast & alt (& under necrotic effects of acute toxic episode, ast > alt). There is also marked increase in both bilirubin (bu & bc). Also, the alp was somewhat elevated but markedly so, suggesting it"s a hepatocellular issue. Igg was normal, so no auto-immune hep & not chronic condition. The only thing it could be is an acute toxic episode. Over weeks, patient kept declining as the drug-induced metabolite kept killing off liver cells. So, the patient became insufficient in liver function so now get to see some markers of this.
