PSC 434 Chapter Notes - Chapter 18: Coronary Vasospasm, Isosorbide Mononitrate, Isosorbide Dinitrate
17 Feb 2019
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Antianginal drugs: angina pectoris is a characteristic sudden, severe, pressing chest pain radiating to the neck, jaw, back and arms. It is characterized by a burning, heavy, or squeezing feeling in the chest. First, it causes dilation of the large veins, Isosorbide dinitrate is used in prophylaxis after mi. resulting in pooling of blood in the veins. Therefore, it is common to take the drug either sublingually or via a transdermal patch, thereby avoiding this route of elimination: typically used on an as needed basis, can be used prophylactically. Isosorbide dinitrate: oral isosorbide dinitrate undergoes denitration to two mononitrates, both of which possess antianginal activity. Isosorbide dinitrate: rapid hepatic metabolism, duration of action about 6 hours. Isosorbide mononitrate owes its improved bioavailability and long duration of action to its stability against hepatic breakdown. Both isosorbide mononitrate and dinitrate can be given. Isosorbide mononitrate: active metabolite of isosorbide dinitrate, no first pass hepatic metabolism, duration of action 6-8 hours.
