CAS BI 107 Chapter Notes - Chapter 8: Escherichia Coli, Nadh Dehydrogenase, Ribose

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Citric acid cycle (pyruvate oxidation; tca cycle; kreb"s cycle): Central metabolic pathway found in all aerobic organisms. Oxidizes acetyl groups derived from sugars (glucose) to co2 and water. Occurs in mitochondria (matrix) in eukaryotic cells: reactions all occur in mitochondria (or the membranes) starting with the substrate (pyruvate) generated in cytoplasm, pathway is a cycle of reactions involving the interconversion of 10 organic acids. Co2 and reducing power are formed from pyruvic acid, with one for carbon intermediate being used up and one regenerated for each turn of the cycle. Removes to electrons, 2 hydrogens, and moves one carbon (co2); acetyl groups transferred to coenzyme. The sum of the reactions for one turn of the cycle is: pyruvate + 3 h2o + 5 coenzymes+ + adp + pi 3 co2 + H2 + atp: co2 is released as a gas or solution, reducing power transferred to electron transport chain to oxygen.

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