BIOMG 1350 Chapter Notes - Chapter 18: Sister Chromatids, Motor Protein, Actin
17 Oct 2016
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Relatively short amount of time, but most dramatic phase. Reorganizes virtually all components and distributes them equally: early phases serve to set stage for m phase. M-cdk drives entry into m phase and mitosis: m-cdk prepares duplicated chromosomes for segregation. Machinery that will pull duplicated chromosomes apart: accumulate throughout, but m-cdk complexes are activated at end of g2. Activating phosphatase cdc25 removes inhibitory phosphates holding m- M-cdk complex can phosphorylate and activate more cdc25: activate more m-cdk. Cohesins and condensins help configure duplicated chromosomes for separation: promote production of m-cdk, sister chromatids. The two copies in a chromosome that remain tightly bound together. Each contain a single, double-stranded molecule of dna. Assemble along length of each chromatid as dna is replicated: chromosome condensation. Reduces mitotic chromosomes to compact bodies that can be more easily segregated within the crowded confines of the dividing cell. Protein complex that help carry out chromosome condensation.
