NBB 301 Chapter 6: Purves Chapter 6: Neurotransmitters and Receptors

• School: Emory University
• Department: Neuroscience & Behavioral Sci
• Course: NBB 301
• Professor: Frenzel Kristen

Document Summary

Choline -- high [] in plasma; taken up by cholinergic neurons; na+-dependent choline co-transporter (cht) Each subunit of receptor has large extracellular region + 4 membrane-spanning regions ---> 5 subunits form channel with central pore (signif larger: muscarine: poisonous alkaloid in mushrooms. Zqa receptors, nmda receptors, kainate receptors: glutamate-gated cation channels; allow na and k. Epscs by nmda slower and last longer than those by ampa. Kainate: feedback mechanism to regulate glutamate release; in presynaptic terminals. Nmda: allows ca too: mg blocks pore at hyperpolarized membrane potentials; depolarization pushes. Mg out of pore: gating requires co-agonist (glycine, 2 glycine-binding subunits and 2 glycine binding subunits, metabotropic glutamate receptors (mglurs, modulate postsynaptic ion channels indirectly ---> inhibit postsynaptic ca and na channels. Cause slower postsynaptic responses that can either excite/inhibit postsynaptic cells. Extracellular ligand-binding domain + intracellular g-protein activating domain: gaba and glycine.