BIOL 3600 Chapter Notes - Chapter IV: Effective Population Size, Small Population Size, Genetic Drift

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20 Nov 2018
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Fisher, haldane, wright amount and kind of genetic variation within and between populations are potentially affected by selection, inbreeding, genetic drift, gene flow, mutation, and recombination. If there are equal numbers of females and males, nf=nm=1/2n ne=n: number of breeding males is smaller than number of breeding females oftentimes since males mate more than once. Population is not changing in size (number of progeny per individual is two) Effective population size over t generations ne. i is effective population size in generation i: linkage disequilibrium ~ statistical association of alleles at different loci. Neutral theory assumes that selection plays minor role in determining maintenance of molecular variants and proposes that different molecular genotypes have almost identical relative fitness: molecular clock ~ constant rate of substitution over time for molecular variants. Population genetic examines impact of various evolutionary factors on amount and pattern of genetic variation in population and how these factors influence future potential for evolutionary change.

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