KH 3650 Chapter Notes - Chapter 1: Respiratory Acidosis, Phosphocreatine, Cardiac Output

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7 Jun 2016

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Oxygen consumption (vo2) is the amount of oxygen taken up and utilized by the body per minute. The oxygen taken into the body at the level of the lungs is ultimately transported by the cardiovascular system to the systemic tissues and is used for the production of atp in the mitochondria of our cells. Because most of the energy in the body is produced aerobically, vo2 can be used to determine how much energy a subject is expending. Vo2 can be reported in absolute terms (l/min) or relative to body mass (ml/kg*min). At rest, nearly all of the body"s energy demands are being met by aerobic metabolic processes, which require oxygen. The mitochondria are the site of aerobic metabolism in the cells (aerobic metabolism will be covered in greater detail in labs later this quarter). Ultimately, oxygen is the final electron acceptor in the electron transport chain, forming water in the process.

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In respiration, air is inhaled into the lungs, which provide a large surface area for transport of oxygen, carbon dioxide, and water to or from the blood. The transported oxygen is delivered to body cells where it oxidizes glucose and fats from food to produce carbon dioxide, water, and thermal energy. The carbon dioxide and water are transported from the cells to the blood and back to the lungs, from which they are exhaled. The exhaled gas is at body temperature and saturated with water, some produced in the glucose and fat oxidation and some additionally drawn from moist lung tissue. Other water-containing streamsâ food, water, perspiration, and excreted waste streamsâmaintain the bodyâs level of hydration.

Suppose an individual inhales air at 20Â°C and 20% relative humidity, and 25% of the inhaled oxygen is consumed in the glucose oxidation reaction. (Under certain conditions, it is reasonable to neglect the oxidation of fats.) A flowchart of the respirationâmetabolism process is shown below. The water in the exhaled gas equals the inhaled water plus the water produced by glucose oxidation plus additional water drawn from the lungs. Qm represents only the heat transferred to or from the body as a consequence of the phenomena just described; not shown are heat and work transferred due to other bodily processes.

(a) Assume a basis of 1 mol bone-dry air (plus the water that goes with it) inhaled at 20Â°C. Draw and fully label a flowchart of the metabolic process, considering only breathing and glucose oxidation as components of the process. You donât need to label the streams between the two units, since this problem will not require determining their masses or compositions. Do a degree-of-freedom analysis of the overall system.

(b) Suppose all of the water and CO2 produced from the glucose oxidation are transported to the lungs and exhaled, and calculate the masses of all components of all labeled streams.

(c) If the individual inhales an average of 500 mL of air per breath and takes 12 breaths per minute, how much water (fluid ounces) must she drink per day to make up for the water she loses by breathing?

(d) Returning to the original basis, estimate the heat (kJ) transferred to or from the body as a consequence of breathing and glucose oxidation, assuming that the glucose is oxidized at 37Â°C and at that temperature ÎHc= -2816 kJ/mol:

1. Which of the following are considered blood vessels within the cardiovascular system? (Select all that apply.)

Veins

Arteries \

Epithelial tissue

Capillaries

Epidermis

2. The middle muscle layer found in the walls of the heart is the __________.

Myocardium

Epicardium

Endocardium

Aorta

3. Blood is transported throughout the body via ___________.

Veins
Arteries

Capillaries

All of the above

4. The right atrium receives blood from all parts of the body except the ______________.

Abdominal cavity

Lungs

Dorsal cavity

Cranium

5. Blood carries which of the following?

Oxygen and cellular waste

Oxygen, nutrients, hormones, enzymes, and cellular waste

Nutrients, hormones, enzymes

Oxygen, nutrients, enzymes

6. Vocal chords are found in the ____________.

Bronchus

Trachea

Larynx and Pharynx

Nasal cavity

7. The trachea is mostly lined by ________________.

Alveoli

Ciliated

mucous membrane

Lung capillaries
Vocal chords

8. Excess CO2 from the body is __________________.

Stored in the pancreas

Digested by cells

Excreted by the respiration process

Used to make ATP

9. CO2 from the body is released into the lungs via _________________.

Ciliated mucous membrane

Alveolar air

Nasal cavity

Bronchial tree

10. The principal function(s) of gas exchange is ____________________.

To supply cells with oxygen

To remove CO2 from the body

Both A and B

Neither of the above

One of the most common chronic conditions affecting the respiratory system is asthma. Asthma is a condition characterized by inflammation of the airways. When an asthma attack is triggered, the airways become even more inflamed and can restrict breathing. Common symptoms during an asthma attacks include coughing, wheezing, tightness in the chest and shortness of breath. Severe asthma attacks can be fatal. People with a family history of asthma are more likely to have the condition. While there is no cure for asthma, proper medical care and a management plan can help to maintain quality of life for people living with asthma. There are different types of asthma, each with their own triggers and management plans. Type Description Exercise-induced Bronchoconstriction (EIB), or Exercise-induced Asthma (EIA) Some people only experience asthma symptoms during exercise. Exercise-induced asthma causes the narrowing of airways during exercise, which restricts the flow of air to and from the lungs. Cold, dry air tends to exacerbate symptoms, while warm, humid air may reduce symptoms. People with exercise-induced asthma should work with their doctor to create a management plan that still allows them to exercise while keeping their symptoms under control. Allergic Asthma Allergic asthma is the most common form of asthma. It is triggered by inhaling allergen particulates, such as dust mites, pollen, pet dander, or mold. The bodyâs reaction to the allergens causes inflammation that results in coughing, wheezing, and other symptoms of asthma. Occupational Asthma Occupational asthma is caused by the frequent inhalation (breathing) of gases, fumes, dust, or other harmful substances in the workplace. Employees working in the chemical or petroleum industries are frequently exposed to chemicals such as Sulphur dioxide or hydrochloric acid, and may develop occupational asthma after prolonged exposure. Childhood Asthma Childhood asthma is usually developed before age 5. It is a condition that affects millions of children. It is vital that childhood asthma is properly controlled to prevent damage to the developing lungs Risk factors: â¢ Allergies â¢ Family history â¢ Frequent respiratory infections â¢ Low birth-weight â¢ Second-hand smoke â¢ Residing in a low-income, urban environment

Asthma symptoms that are triggered by exposure to pollen, pet dander, mold, or dust mites is indicative of which of the following types of asthma:

Occupational asthma

Childhood asthma

Allergic asthma

Exercise-induced asthma

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11. Which of the following is an attribute of a scientifically literate person?

A. Creates templates for understanding

B. Constructs hypothetical arguments for discussion

C. Respects the rights of self determination

D. Uses scientific evidence to understand the natural world

E. Reports on social phenomena consistently

12. Which of the following does not contribute to the Calorie intake of a person?

A. Protein

B. Carbohydrate

C. Fat

D. Alcohol

E. Water

13. Which of the following is not a technique used to measure body composition?

A. Skin-fold calipers

B. Bod PodÃ

C. Body mass index

D. Hydrostatic weighing

E. Light absorption technique

14. Which of the following behavioral techniques supports healthy body weight changes?

A. Feasting

B. Fasting

C. Goal setting and a plan

D. Eating vegetables and meat

E. Regularly measuring body composition

15. The purpose of the warm-up is to:

A. Slowly increase the pulse rate to an aerobic level.

B. Facilitate vascular changes (splenic shunt) to accommodate aerobic exercise.

C. Gear up the energy metabolism, i.e., increase the delivery of oxygen and nutrients to the working muscle, and raise the temperature to an optimal level for energy production.

D. Increase the elasticity of the muscle fibers, which helps to prevent muscle, tendon, ligament, and joint injuries, as well as improve muscle contraction and preserve muscle glycogen in addition to reducing the amount of lactic acid build-up in the muscles.

E. All of the above

16. Which of the following reflects an improvement in cardiovascular health resulting from regular engagement in aerobic exercise?

A. Increased lean body mass

B. Increase in high-density lipoprotein cholesterol (HDL)

C. Stress relief

D. Improvement in sleep pattern

E. Reduced risk for developing certain types of cancer

17. The purpose of a cool-down is to:

A. slowly decrease pulse rate.

B. decrease core body temperature.

C. slowly constrict blood vessels.

D. continue adequate supply of blood to the brain, and facilitate removal of metabolic waste products from the muscles.

E. All of the above

18. A person trying to gain lean body mass has:

A. increased fluid needs.

B. decreased fat needs.

C. altered fitness needs.

D. increased protein and strength training needs.

E. decreased electrolyte needs.

19. Vitamin A in the form of _____ is used to treat acne.

A. retinol

B. retinal

C. retinoic acid

D. beta-carotene

E. lycopene

20. Which of the following is a genetic disease for which a low intake of copper is a component of treatment?

A. Pellagra

B. Wilsonâs disease

C. Hemochromatosis

D. Beriberi

E. Goiter

21. Which of the following nutrients is used to treat scurvy?

A. Folate

B. Riboflavin

C. Vitamin C

D. Niacin

E. Vitamin D

22. Which of the following groups is at highest risk for hemolytic anemia?

A. Premature infants

B. Elderly people who do not get exposure to sunlight

C. Pregnant women

D. Teenagers who do not drink enough water

E. Someone who does not consume animal meat or products

23. Iron deficiency causes:

A. microcytic normochromic anemia.

B. macrocytic hypochromic anemia.

C. microcytic hypochromic anemia.

D. macrocytic normochromic anemia.

E. macrocytic hyperchromic anemia.

24. Acrodermatitis enteropathica is caused by a deficiency of:

A. iron.

B. zinc.

C. chromium.

D. choline.

E. molybdenum.

25. Which of the following is required for the absorption of vitamin B₁₂?

A. A coenzyme

B. Intrinsic factor

C. Vitamin C

D. Bile acids

E. None of the above

26. Which nutrient potentiates the action of insulin?

A. Magnesium

B. Fluoride

C. Chromium

D. Selenium

E. Iodine

27. Which mineral is a central component of vitamin B₁₂?

A. Iron

B. Copper

C. Cobalt

D. Zinc

E. Molybdenum

28. Iodine is a component of:

A. hemoglobin.

B. myoglobin.

C. intrinsic factor.

D. insulin.

E. thyroxine.

29. Which of the following statements is not true regarding the diagnosis of a nutritional deficiency?

A. Dietary records should demonstrate low intake for that nutrient.

B. Blood levels should demonstrate high body levels of the nutrient.

C. Tissue levels should demonstrate low body levels of the nutrient.

D. Nutrient supplementation should correct the deficiency symptoms.

E. Clinical deficiency symptoms should be compatible with a low dietary intake.

30. Vitamin C helps maintain tissue integrity by:

A. neutralizing foreign proteins.

B. creating an alkaline cell environment.

C. recognizing cell boundaries.

D. forming collagen to bind cells together.

E. increasing inflammation

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KH 3650 Chapter Notes - Chapter 1: Respiratory Acidosis, Phosphocreatine, Cardiac Output

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