AS.020.305 Chapter 12: Exam 2 Notes (dragged) 23
Document Summary
Catalyzes oxidation of cytochrome c (reduced) by o2, the terminal electron acceptor of the electron transport process, complex ii, catalyzes the oxidation of fadh2 by coq. Oxidative phosphorylation: atp synthesis, carried out by f0f1 atp synthase complex in inner membrane of mitochondria. Tissue hypoxia: decreased etc causing decreased atp production, glycolysis increases causing lactic acidosis. Electron transport chain inhibitors: cn (irreversible binding to cytochrome a/a3 preventing e transfer), co (binding to cytochrome a/a3). Electron transport chain uncouplers: decrease proton gradient, decreased atp. Reactive oxygen species: partially reduced o2 produces reactive oxygen species like superoxide, hydrogen peroxide, hydroxyl radical, pmns use oxygen radicals to kill bacteria, reactive oxygen species accumulation causes damage to tissues, defenses include: superoxide dismutase and catalase.
