PHYS 799 Chapter Notes - Chapter 15: Chronic Liver Disease, Hepatic Encephalopathy, Acute Liver Failure
23 Apr 2019
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* bolded text and tables were called out as need to know or were comments by dr. deyrup. The liver: large functional reserve, regenerates 60% mass in 4-6 wks. Clinical syndromes: hepatic failure end point of progressive damage to liver; 80- Acute and chronic hepatitis: morphology resource on liver patterns & table 15-5, entire liver can be involved or just patchy areas, acute hepatitis show less inflammation and more hepatocyte death than chronic hepatitis, hepatocyte injury: 1. Igm anti-hdv most reliable indicator of recent exposure. Coinfection indicated by igm against hdv ag & hbcag: hepatitis e is endemic in equatorial regions & epidemic, the inflammatory cells in both acute and chronic viral hepatitis are mainly t cells, serology to differentiate from toxin-induced hepatitis. Isoniazid idiosyncratic hepatotoxin causing chronic hepatitis: drugs like minocycline, nitrofurantoin induce autoimmune hepatitis; only respond to treatment sometimes, progressing to cirrhosis even after agent withdrawn. Infectious agents (tb) systemic sarcoidosis, primary biliary cirrhosis.
