BIOL 3096 Chapter Notes -Zipper, Vinblastine, Paclitaxel
3 Mar 2014
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Initially both motor heads are bound to adp. 10/28/13: as the neck linker of the first slackens, the first motor head also is releasing from the actin, and the second motorhead is binding to the microtubule, exchanging adp for atp, Zipping its neck linker, and restarting the whole process. Microtubules: basically used to transport internal molecules, there are inhibitors of microtubules which cause them to break down, they cause internal movement to stop, which could change the structure of the cell, but more. Inhibitors: colchicine, colcemide, vicristine, vinblastine, taxol importantly, they will cause mitosis to cease, which require microtubules to a great extent. 2 | s y d n e s: zwichen (z) line, in the middle of the i-band. Sarcomere the space between two z lines, containing a complete a-band and two halves of an i-band (one on either side of the a-band)
