PSIO 431 Chapter Notes - Chapter 3: Complement Membrane Attack Complex, Complement Component 3, C3B
14 Jun 2019
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Given what you have learned about the complement pathways, would you expect a c1 or a. I would expect a c3 deficiency to be more clinically serious because the c3 protein is essential for activating the complement system in the presence of an invasion. The invader triggers the c3 protein to be cleaved into two fragments (c3a and c3b). C3b ultimately initiates the complement system"s response by the triggering the culmination of proteins, stimulating inflammation, and forming the membrane attack complex. Thus, a c3 deficiency would result in the bodies inability to generate c3b and it would be unable to form the membrane attack complex for lysis of the invader. Since c3 is involved in removing antigen/antibody complexes, patients deficient in c3 can get lupus autoimmune disease or repeated infections. C3 deficiency can cause an underactive immune response due to it normally responsible for activating the complement system.
