BIO SCI 47 Chapter Notes - Chapter 8: Macrophage, Immunosuppression, Autoimmune Disease
10 May 2018
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Immunity, Stress, and Disease
● Psychoneuroimmunologists determine how what goes on in your head affects your
immune system
● The autonomic nervous system sends nerves into tissues that form or store the cells of
the immune system and eventually enter the circulation
○ Immune system tissue is sensitive/receptive to hormones released by pituitary
● First evidence that the brain was involved in the immune system was a century ago
when someone waved a fake rose in front of someone’s nose and that person got an
immune response
● Conditioned Immunosuppression
is when you can replace a drug with a conditioned
stimulus and have the same effect
○ Link between nervous system and immune system
Immune System Basics
● the immune system can remember what every cell in your body looks like, and any cells
that lack your distinctive cellular signature (for example, bacteria) are attacked
○ Immune system remembers what the bad guys look like so next time they’re
better prepared
● Lymphocytes and monocytes are white blood cells
○ The two classes of lymphocytes are B Cells and T Cells
■ Both originate in bone marrow
■ T Cells mature in the thymus
● B Cells create antibodies
● T cells bring about cell-mediated immunity
○ When a bad guy enters the body it is recognized by a macrophage which
presents foreign body to helper T Cell
○ Alarm is sounded and T Cells multiply
○ Cytotoxic killer cells attack and destroy infectious agent
● AIDS knocks out T Cells
● B Cells cause antibody-mediated immunity
○ Once the macrophages and T Cells communicate, the T Cell stimulates the B
Cells to multiply
■ B Cells generate and differentiate antibodies, large proteins that bind and
recognize infectious agents
Document Summary
Psychoneuroimmunologists determine how what goes on in your head affects your. The autonomic nervous system sends nerves into tissues that form or store the cells of the immune system and eventually enter the circulation. Immune system tissue is sensitive/receptive to hormones released by pituitary. First evidence that the brain was involved in the immune system was a century ago when someone waved a fake rose in front of someone"s nose and that person got an immune response. Conditioned immunosuppression is when you can replace a drug with a conditioned stimulus and have the same effect. Link between nervous system and immune system. The immune system can remember what every cell in your body looks like, and any cells that lack your distinctive cellular signature (for example, bacteria) are attacked. Immune system remembers what the bad guys look like so next time they"re better prepared. Lymphocytes and monocytes are white blood cells.
